Patient's question:
Is it possible for a baby to have hemolytic disease if the man has blood type O and the woman has blood type B?Doctor's answer:
Analysis of the condition: Neonatal hemolytic disease (hemolytic disease of the newborn due to incompatibility between mother and fetus) is an autoimmune hemolytic disease caused by the reaction between maternal antibodies and fetal red blood cells due to the incompatibility of blood types between the pregnant woman and the fetus.Recommendations: Neonatal hemolytic disease, also known as hemolytic disease of the newborn due to incompatibility between mother and fetus, is a hemolytic disease caused by the same-species immune reaction of the mother to fetal red blood cells. Both Rh blood type and ABO blood type incompatibility can cause this disease, but the former is more severe. It is the most common cause of pathological jaundice in newborns, as well as the most severe disease causing elevated bilirubin in newborns. Currently, 26 blood group systems and 160 blood group antigens have been identified. In China, ABO blood type incompatibility is the most common, while Rh blood type incompatibility is less frequent, but the clinical manifestations of Rh hemolytic disease are more severe than those of ABO blood type incompatibility. MN hemolytic disease is the rarest. For example: In Shanghai from 1959 to 1977 over 18 years, a total of 835 cases of neonatal hemolytic disease were detected, including 712 cases of A, B, O hemolytic disease (85.3%), 122 cases of Rh hemolytic disease (14.6%), and 1 case of MN hemolytic disease (0.1%).