RNAi: A Guide to Gene Silencing: A Frontier in Modern Biotechnology

Author: Han Nong
Publisher:
Publish Date: 2005-01-01
Features: RNA genomics research is booming. Related studies on RNA were ranked as one of the top ten advances in 2002 by the U.S. journal Science. It has been discovered that double-stranded RNA can inhibit the expression of genes with specific sequences. Leveraging this characteristic of RNA, scientists can strongly silence genes in vitro—known as RNA interference (RNAi)—thus opening up a new and rapidly developing field in life sciences research. RNA interference technology can accelerate our understanding of human gene functions, and researchers hope to utilize this technology to design novel gene drugs that inactivate disease-causing genes. This book is written by renowned experts in the field, offering up-to-date, comprehensive, and systematic content with high reference value. The main topics include the basic concepts of RNA interference, biochemical research, the regulation of double-stranded RNA on the genome, shRNA-mediated silencing in mammalian gene expression, the ribozyme superfamily, and strategies for gene silencing in various animal models using RNA interference. This book is suitable for teaching and research personnel in life science-related fields such as developmental biology, cell biology, genetics, genomics, neurobiology, and molecular biology, as well as undergraduate and graduate students.