What are the causes of epilepsy?

Patient's question:

Ranking of Hospitals for Treating Pediatric Epilepsy / What are the Causes of Epilepsy

Doctor's answer:

Common causes of epilepsy include:
1. Congenital malformations: such as chromosomal abnormalities, congenital hydrocephalus, microcephaly, corpus callosum agenesis, and cortical dysgenesis.
2. Prenatal and perinatal diseases: birth injuries are a common cause of symptomatic epilepsy in infancy.
3. Post-heatstroke sequelae: severe and prolonged high-temperature convulsions can lead to brain damage, including neuron loss and gliosis, primarily in the medial temporal lobe, especially the hippocampus.
4. Cranial brain injury: individuals with post-traumatic epilepsy often have depressed fractures, torn dura mater, and local neurological signs, along with memory impairment after long-term damage.
5. Infections: various bacterial meningitis, brain abscesses, granulomas, viral encephalitis, and parasitic diseases such as pork tapeworm, schistosomiasis, and toxoplasmosis.
6. Poisoning: lead, mercury, carbon monoxide, ethanol, strychnine, isoniazid poisoning, as well as systemic diseases like preeclampsia and uremia, can all trigger epilepsy.
7. Intracranial tumors
8. Cerebrovascular diseases: while epilepsy caused by vascular malformations or subarachnoid hemorrhage tends to occur at a younger age, post-stroke epilepsy is more common in middle-aged and elderly individuals, especially embolic stroke, thrombotic stroke, and multiple lacunar infarctions. Hypertensive encephalopathy is also often associated with epilepsy.
9. Nutritional and metabolic diseases: children with rickets frequently develop epilepsy. In adults, conditions such as insulinoma-induced hypoglycemia, diabetes, hyperthyroidism, hypoparathyroidism, and vitamin B6 deficiency can all lead to seizures.

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