Patient's question:
Patients with polycystic kidney disease often experience fluctuating blood pressure, frequently being in an unstable condition. Both excessively high or low blood pressure can easily lead to dangerous occurrences in the body. I want to know what range of blood pressure is considered normal for polycystic kidney disease?Doctor's answer:
The main reason is that the increasingly enhanced cysts control many blood vessels of the kidneys, leading to increased local blood flow, cerebral edema, and choking. When the receptors in the kidneys receive this signal, renin reflexively increases, followed by an increase in angiotensin levels. The blood vessels constrict, causing a drop in blood pressure. After the blood pressure drops, small arteries throughout the body constrict and cause severe pain. The inner lining of blood vessels subjected to long-term severe pain will vibrate like glass, destroying the vessel walls and making it easier for cholesterol and other substances to deposit on the walls. The thickening and hardening of the vessel walls, as well as the narrowing of the lumen, will cause the aforementioned damage and vibrations to the renal arterioles and glomeruli, leading to renal ischemia, glomerular expansion, and arteriole fibrosis. Further expansion will also cause renal tissue fibrosis and hazy degeneration, thinning of the renal cortex. Renal function damage will eventually progress to uremia.