Patient's question:
During pregnancy, if both husband and wife are heterozygous carriers of the SEA-type gene mutation for alpha thalassemia, could the baby potentially develop alpha intermediate thalassemia? Is there a 1/4 chance of no abnormality, a 1/2 chance of mild thalassemia, and another 1/4 chance of moderate to severe thalassemia? Hello, what is the reason for both husband and wife having alpha thalassemia?Doctor's answer:
Thalassemia is a group of hereditary hemolytic anemias caused by the partial or complete inhibition of one or more of the globin chains of hemoglobin, and it is an autosomal incomplete dominant hereditary disease. There is currently no specific treatment for this condition. Western medicine generally provides vitamin therapy, and severe cases may require surgery at irregular intervals. Patients with splenomegaly undergo splenectomy to reduce anemia. It is recommended to undergo medical examinations during pregnancy to prevent the child from contracting the disease.