What are the clinical manifestations of hemolytic reactions?

Patient's question:

My friend had a thorough check-up two months ago and discovered she was pregnant. In the past few days, she went for a prenatal examination. My friend's blood type is O-negative (+), and her husband's is A-positive. It is said that such a combination may lead to hemolytic disease in the child. Can this be detected through a thorough check-up, and what interference does it pose to the fetus?
Hello, what are the symptoms of hemolysis?

Doctor's answer:

Clinical manifestations: Jaundice of the skin and sclera: Infants with hemolysis have of the skin and sclera (also known as the white of the eyes). Anemia varies in severity: severe cases may lead to heart failure and generalized edema. Enlarged liver and spleen: Mild cases show no significant reduction, while severe cases have liver and spleen shrinkage. Fever: Often accompanied by fever. Anemia varies in severity, and when, surgery is one of the main treatments. However, in certain hemolytic conditions, surgery also carries certain risks. For example, in autoimmune hemolytic anemia, surgery in patients with varying degrees of severity may trigger a hemolytic reaction; and in PNH patients, surgery may also cause massive hemolysis. surgery may also suppress the bone marrow's self-healing mechanism. Therefore, surgery should be avoided as much as possible.

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