Patient's question:
What should I do if the hepatitis B virus copy indicator (HBV-DNA) alternates between negative and positive again?Doctor's answer:
Still, one should focus on treatment. This phenomenon is an expression of the persistence of the hepatitis B virus. Its harm stems from the mobility and pathological changes of the hepatitis B virus, which continuously damages and destroys the liver. The repeated cycles of liver cell inflammation, necrosis, and regeneration gradually lead to fibrosis, progressing to liver fibrosis and ultimately cirrhosis. Due to these reasons, it is necessary to continue treatment to reduce the incidence of cirrhosis to the lowest possible level. If one loses confidence in treatment due to the recurring alternation of negative and positive HBV-DNA results and abandons or terminates treatment, it may lead to adverse consequences such as cirrhosis or liver cancer.