Does diabetes cause male infertility?

Patient's question:

I and my partner really want to have a child, but she has not been pregnant. I was diagnosed with azoospermia, and I am currently undergoing diabetes treatment. I would like to ask if diabetes can cause azoospermia?

Doctor's answer:

The primary cause of azoospermia (absence of sperm) due to diabetes is the metabolic disorder of glucose in diabetes. This disrupts the glucose utilization process in Leydig cells (which secrete male hormones) and anterior pituitary cells (which secrete gonadotropins) as well as other hormone-producing cells, leading to insufficient energy supply for sperm motility. This severely affects sperm activity, resulting in infertility. However, there are many other causes of azoospermia. It is recommended that you seek medical examination and treatment early to avoid further harm to your health caused by the disease.

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