Patient's question:
The father of a colleague was carefully diagnosed with severe aplastic anemia a few weeks ago. I would like to ask what causes severe aplastic anemia?Doctor's answer:
1. Drugs are the most common causative factors of disease.2. The relationship between chemical toxicants benzene and its derivatives and aplastic anemia has been established by many experimental studies. Benzene easily enters the human body and is primarily fixed in fat-containing tissues. In chronic benzene poisoning, benzene mainly accumulates in bone marrow. The bone marrow toxic effects of benzene are caused by its metabolites, which can inhibit the DNA and RNA synthesis of self-repair progenitor cells and damage chromosomes.
3. Viral hepatitis is generally believed to cause the occurrence of severe aplastic anemia in viral hepatitis patients at a rate of 0.05% to 0.9%. The incidence of severe aplastic anemia in these patients is 3.2% to 23.9%. 80% of severe aplastic anemia patients are caused by hepatitis C virus.