What is the effect of a larger Y chromosome in males on pregnancy?

Patient's question:

Detailed medical condition and consultation purpose: What is the impact of male chromosomal abnormalities on pregnancy? How should it be paid attention to?

Doctor's answer:

Hello, our country uses Y≥18 as the standard for a large Y chromosome, which is caused by length variations in the Y chromosome's long arm heterochromatic region. If the Y chromosome is larger, if you are having a girl, it has no impact.
Suggestions: If you are pregnant with a boy, it may lead to issues such as miscarriage or fetal abnormalities. Chromosomes are aggregates formed by the deep compression of hereditary material with genetic properties within cells. Therefore, this is inevitable, and it cannot be avoided through personal efforts. If you want to have a baby, it is best to undergo pre-pregnancy testing to ensure everything is optimal before conception. This can help minimize the risks as much as possible.

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