What should be done if a three-year-old girl has an enlarged spleen?

Patient's question:

My son had a fever and cough last week, and he's been having stomach pain this week. Today, I took him to the internal medicine department and had an ultrasound done. There's splenomegaly. What should I do? Is it caused by the fever? What should I do?

Doctor's answer:

Enlarged spleen, its etiological classification can be summarized into two categories: one is infectious splenomegaly; the other is non-infectious splenomegaly. There are numerous causes of splenomegaly, and the mechanisms by which each disease causes splenomegaly are also different. Sometimes, the mechanism by which one cause leads to splenomegaly may involve multiple factors.
The upper boundary of the liver in children is generally at the 4th intercostal space along the right midclavicular line, while the lower boundary is usually 1 to 2 cm below the right costal margin, and it is more easily palpable below the xiphoid process, approximately 2 cm. The spleen cannot be palpated below the costal margin along the left midclavicular line or exceeds 1 cm, with a soft texture and superficial position.

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