What should be done if a child has ABO hemolytic disease?

Patient's question:

Hello, your child has ABO hemolysis. What should you do if the child suffers from ABO hemolysis? Does it need to be treated in the hospital?

Doctor's answer:

Hemolytic disease of the newborn refers to immune hemolysis caused by incompatibility between the blood types of the mother and the infant. In China, the majority of cases involve ABO blood type incompatibility, while Rh incompatibility is less common, and other blood group systems such as MN and Kell are rare. The severity of symptoms varies greatly in this condition, with ABO incompatibility generally causing milder symptoms compared to Rh incompatibility. Infants often develop jaundice within 24 hours of birth or the next day, which rapidly worsens. As jaundice deepens, anemia, hepatosplenomegaly may occur, and severe cases can lead to bilirubin encephalopathy. In cases of severe hemolysis due to Rh incompatibility, infants are born with severe anemia, which can result in heart failure, generalized edema, and even stillbirth.

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