Pharmacological bioavailability

Author: H. van de Waterbeend (USA), H. Lennartz (Switzerland), P. Artusson
Publisher:
Publish Date: 2007-01-01
Features: The study of drug bioavailability is one of the key research areas in drug discovery and new formulation development. This book summarizes existing strategies and methods for predicting and studying oral drug absorption and bioavailability, divided into five parts, providing an in-depth exploration of:
1. Physicochemical properties of drugs, determination and prediction of solubility;
2. Experimental studies on drug permeability through biological membranes and oral absorption;
3. Research progress on carrier proteins, intestinal wall metabolism, and their effects on the absorption process;
4. Computational methods and models for predicting permeability, absorption, and bioavailability;
5. Issues encountered in drug development.
This book not only assists drug development personnel in selecting candidate compounds suitable for clinical use but also guides pharmaceutical researchers in developing new formulations. It is equally beneficial for those engaged in drug interaction research.