From Natural Products to the Creation of New Pesticides -- Principles and Methods

Author: Wu Wenjun, Editor-in-Chief
Publisher:
Publish Date: 2006-03-01
Features: This book aims at the creation of new pesticides. From the perspective of pesticide science, it first describes the extraction, separation, structural identification, and evaluation methods of active components from natural products. It then introduces the principles and methods for developing commercialized pesticides directly from plant extracts or microbial secondary metabolites. Additionally, it explores the principles and methods for optimizing natural lead structures, including bioisosteric substitution, pharmacophore modeling, quantitative structure-activity relationships (QSAR), and virtual screening. The book also covers pesticide mechanism of action research, particularly receptor localization, receptor protein isolation, and structural studies for discovering and investigating new targets. Two case studies of natural product pesticide research are provided. This book serves as a reference for graduate students, researchers, and educators engaged in pesticide research and development, especially those involved in the creation of new pesticides.