Patient's question:
"Trimethadione" has an effect on premature ejaculation. What are the specific drug names? Pharmacies all say they don't know. Please recommend some specific drug names containing trimethadione that I can buy. Thank you.First follow-up question: Please tell me the specific drug names, and I will use them cautiously. Please.
Doctor's answer:
1. Serotonin Reuptake InhibitorsSerotonin reuptake inhibitors can inhibit the reuptake of serotonin, delaying male orgasmic impulse. Commonly used drugs mainly include clomipramine, trazodone, fluoxetine, sertraline, paroxetine, and dapoxetine.
2. PDE5 Inhibitors
PDE5 inhibitors can also be used for premature ejaculation treatment. Their possible peripheral mechanisms include regulating the contraction responses of the vas deferens, seminal vesicles, prostate, and urethra, as well as prolonging the total duration of erection. Possible central mechanisms involve reducing central sympathetic outflow.
3. Local Application of Drugs to the Penis
Topically applied anesthetic drugs can reduce local sensitivity of the penis and are used for premature ejaculation treatment. However, repeated use may lead to decreased penile sensation, anhedonia, mild erectile dysfunction, and decreased libido, while also posing the possibility of vaginal drug absorption.
4. α-Adrenergic Receptor Blockers
α-Adrenergic receptor blockers can selectively or non-selectively block α-adrenergic receptors on the vas deferens, prostate, seminal vesicles, and smooth muscle of the posterior urethra, causing muscle relaxation, reduced peristalsis, and prolonged refractory period. Commonly used drugs include terazosin, doxazosin, and tamsulosin.