How does escitalopram hydrochloride fail to be effective against premature ejaculation?

Patient's question:

Some urologists are using sertraline hydrochloride to treat premature ejaculation, and there are also some papers on this topic online, showing a certain therapeutic effect. The raw material of sertraline hydrochloride is the same as that of dapoxetine, an anti-premature ejaculation drug developed by Johnson & Johnson in the United States. However, after I took a box (14 pills), I didn’t feel any significant effect. Why is sertraline hydrochloride ineffective against premature ejaculation?

Doctor's answer:

There are related reports that this medication has a certain efficacy, but it doesn't mean it's suitable for everyone or that it works for everyone. Taking it 30 minutes to 1 hour before sexual activity may yield better results. If you don't see the desired effect after taking it, it's recommended to switch to another medication. Additionally, if you take it regularly, meaning every day regardless of whether you have sexual activity, it may take longer to take effect. On the other hand, taking it just before sexual activity might be more effective. It is advised to take the medication 30 minutes to 1 hour before sexual activity.

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