What is the difference between free prostate-specific antigen and total prostate-specific antigen?

Patient's question:

Hello doctor, I am 30 years old this year! Due to training reasons, the pressure is especially great, and my body has recently appeared many conditions again! I would like to consult, hello, what is the difference between free prostate-specific antigen and total prostate-specific antigen? Can you give me many suggestions or clarify things for me? Thank you!

Doctor's answer:

Hello! The ratio between free prostate-specific antigen (fPSA) and total prostate-specific antigen (tPSA) is used to predict the possibility of prostate cancer. If this ratio is below 0.16 and the tPSA is above 4, there should be high suspicion of prostate cancer, and it is recommended to combine other indicators for prediction. If this indicator is abnormal, the final confirmation of prostate cancer will depend on a prostate needle biopsy.

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