Does sulfasalazine cause erectile dysfunction?

Patient's question:

I have had this intestinal inflammation for two years. Taking medication for treatment has always been inconsistent, but the aminosalicylic acid I took this time was quite effective. After persisting with it for a period, it didn't recur. Now I have been off the medication for several months, but I've noticed I have premature ejaculation. Could aminosalicylic acid cause premature ejaculation?

Doctor's answer:

Any drug has certain side effects, and long-term use can affect liver and kidney function, which may also impact normal sexual function. If the sexual dysfunction is caused by this medication over a long period, it may be worth considering switching to a new drug and adjusting the dosage. Of course, it's also necessary to check for other adverse factors. The factors that cause male sexual dysfunction are relatively complex and may not necessarily be caused by medication.

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