Probenecid and penicillin-class antibiotics

Author: Wu Xiaohui
Publisher:
Publish Date: 2006-10-01
Features: The purpose of writing this book is to introduce the pharmacokinetic characteristics of probenecid itself, as well as the trajectory and progress of domestic and international research on the combined use of probenecid with β-lactam antibiotics. These research contents can be generally divided into two parts: one part treats probenecid as a conventional tool drug to observe some basic characteristics of pharmacokinetic parameters of various β-lactam antibiotics; the other part involves the combined use of probenecid with various β-lactam antibiotics for the treatment of diseases. The book describes the specific regimens of this combined use (such as dosage and administration) as detailed as possible to provide references for clinicians when using probenecid with β-lactam antibiotics. Since research in this field has just begun in China, the book mainly references foreign-related research literature. As people's understanding of the special value of probenecid in optimizing the pharmacokinetic/pharmacodynamic (PK/PD) characteristics of β-lactam antibiotics continues to deepen, more scholars should pay attention to and engage in research in this area, which will undoubtedly benefit the conservation of antibiotic resources and the scientific and rational use of β-lactam antibiotics. This is far more realistic than expecting more and newer antibiotics to be developed.