Biological Chip Technology and Applications Detailed Explanation

Author: G. Hademan
Publisher:
Publication Date: 2006-09-01
Features:
In recent years, the application of biochip technology for gene expression profiling has become a common molecular biology technique. The publication of whole-genome sequence information and technological advancements have enabled biochip technology to be applied in broader areas such as genomics, making it possible to analyze the expression profiles of most genes in the biological transcriptome. I remember being so excited when I first saw a real biochip. This happened in 1995, when Synteni Company demonstrated biochip technology at the DNAX Center in Palo Alto, and I was a postdoctoral researcher at the time. In 1998, as a researcher in the upstream technology field, I finally had the opportunity to become a part of this research area. At that point, DNA microarray technology had become quite mature, and chip fabrication techniques and data analysis methods had also become more complex.
The motivation for writing this book originated from a course titled "Introduction to Microarray Technology" that I organized through the University of California San Diego Bioscience Extension in March 2002. This course provided an important platform to discuss the new advancements and development trends in biochip technology. It offered detailed introductions to microarray and gene chip technologies, the evolving research in biochip studies, microfluidic technology, devices, spotting, and detection methods, as well as the technical standards for methods and reagents required for successful gene expression profiling and SNP analysis. This has become an annual event, and a summary of the 2003 conference was published.
This book serves as a technical manual guiding biochip researchers in laboratory operations. It primarily covers four aspects: major biochip technologies; biochip laboratories and related equipment; knowledge of statistical analysis and data management for biochips; and the applications of biochips. The book includes extensive technical details and practical tips in biochip technology, with a focus on how to prepare high-quality biochips. It is suitable for technical personnel in biochip research and can also serve as a reference for graduate students in related fields.