What are the clinical manifestations of Down syndrome?

Patient's question:

A good friend's grandfather is hospitalized due to Down syndrome. He has been receiving treatment for a long time, but he doesn't have a very good understanding of the disease and doesn't know what its clinical manifestations are. What are the clinical symptoms of Down syndrome?

Doctor's answer:

Hello, it is a pleasure to answer for you: The main clinical manifestations of Down syndrome are that children have obvious special facial features, such as wide-set eyes, low nasal bridge, small palpebral fissures, and slanted outer canthi of the eyes. There may be epicanthal folds, low-set ears, and the tongue often sticks out with excessive drooling. The body is relatively short, the head has a shorter anteroposterior diameter, the occiput is relatively flat, bone age is often delayed compared to children of the same age, and the limbs are relatively short, etc.

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