What are the causes of epididymal malformations?

Patient's question:

I don't have any bad habits, and I look quite healthy. I've been married to my wife for several years and have been trying to get pregnant. But for some reason, I just can't conceive. Also, I have some cysts in my epididymis, but there are no other symptoms. People say infertility is caused by epididymal malformation. What should I do?

Doctor's answer:

The etiology of epididymal malformations remains unclear. Since patients with cryptorchidism often have epididymal malformations, their recurrence may be related to endocrine dysfunction during embryonic growth and development. Due to abnormally high testosterone levels, mesonephric tubules and mesonephric ducts fail to develop or develop incompletely, resulting in various types of epididymal malformations. If the mesonephric ducts fail to develop at all, it can lead to congenital absence of the epididymis and vas deferens. Epididymal conditions tend to recur, requiring long-term oral medication. Additionally, proper diet and abstinence from sexual activity should be maintained to prevent recurrence.

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