What factors are related to epididymal malformations?

Patient's question:

I don't have any bad habits, and I look quite healthy. I've been married to my wife for several years and have been trying to get pregnant, but for some reason, it just isn't working. Also, I have some cysts in my epididymis. What factors are associated with epididymal abnormalities?

Doctor's answer:

The etiology of epididymal malformations is still unclear. Since patients with cryptorchidism often have epididymal malformations, their recurrence may be related to endocrine dysfunction during embryonic growth and development. Due to excessively high testosterone levels, mesonephric tubules and mesonephric ducts may fail to develop or develop incompletely, leading to various types of epididymal malformations. If the mesonephric ducts fail to develop at all, it can result in congenital absence of the epididymis and vas deferens. The recurrence of epididymal malformations may be associated with endocrine dysfunction during embryonic growth and development.

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