Chiral synthesis - asymmetric reactions and their applications

Author: Lin Guoqiang et al.
Publisher:
Publish Date: 2003-02-01
Features: This book emphasizes both fundamental knowledge and the latest research findings, serving as a textbook for undergraduate and graduate students in organic chemistry, pharmaceutical chemistry, and fine chemical engineering, as well as a reference for researchers, teachers, and technical personnel in the pharmaceutical industry, fine organic chemical engineering, and related fields. The book systematically discusses the core topic of modern synthetic organic chemistry—chiral synthesis (also known as asymmetric synthesis). It consists of 8 chapters:
Chapter 1 introduces the basic concepts and methodologies of this field;
Chapter 2 discusses alkylation reactions of carbon-based compounds;
Chapter 3 covers aldol condensation, allylation reactions, and related reactions;
Chapter 4 explores asymmetric oxidation reactions;
Chapter 5 elaborates on asymmetric Diels-Alder reactions and other cycloaddition reactions;
Chapter 6 describes asymmetric catalytic hydrogenation of alkenes, enamines, and ketones, as well as other reduction reactions;
Chapter 7 illustrates the application of asymmetric reactions in the synthesis of complex natural products with examples;
Chapter 8 includes enzyme-catalyzed synthesis, other synthetic methods, new concepts, and the latest advancements in asymmetric synthesis. By citing a large number of reported achievements, the book provides a comparative analysis of the advantages and limitations of different synthetic pathways.