What are the causes of nonliquefaction of semen

Patient's question:

Married for many years without pregnancy, checked and found suffering from azoospermia, what are the causes of azoospermia

Doctor's answer:

Ejaculate liquefaction failure is caused by a deficiency or destruction of proteolytic enzymes, leading to endocrine disorders in the enzyme system. As a result, many patients' semen remains unliquefied after being placed for 1 hour, or liquefies incompletely with excessively high viscosity. In such cases, sperm cannot migrate, naturally resulting in infertility. This condition is associated with infections of accessory glands that impair the excretion of proteolytic enzymes, fibrinolytic enzymes, and seminal liquefaction factors, preventing the liquefaction of semen.

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