After a high-risk result in the Down syndrome screening, have there been any babies born who are normal?

Patient's question:

No

Doctor's answer:

Hello, the Down syndrome screening is only a preliminary test for trisomy 21. A high risk does not necessarily mean the presence of trisomy 21, so the proportion of normal amniocentesis results is still very high. However, amniocentesis needs to be performed to rule it out.