The female has a balanced chromosomal translocation, what is the success rate of IVF with preimplantation genetic diagnosis?

Patient's question:

Had two miscarriages in the Qing court, each lasting about 52 days. After examination, the female's chromosomes 6 and 7 were balanced translocations, while the male was normal.

Doctor's answer:

Hello! The female has a balanced translocation. Theoretically, the eggs produced are 1/18 normal, 1/18 balanced, and the rest are unbalanced. This can lead to an increased rate of early miscarriage in the female and also an increased risk of congenital defects in the fetus.

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