What are the causes of immunological infertility?

Patient's question:

What are the causes of immunological infertility?

Doctor's answer:

Here are the reasons for immunological infertility:
1. Due to excessive sexual frequency. This is one of the important reasons leading to immunological infertility in women.
2. Due to autoimmune factors: This refers to the leakage of male sperm, seminal fluid, or female eggs and reproductive tract secretions, hormones, etc., from the reproductive tract into surrounding tissues, triggering an autoimmune response.
3. Due to local immune factors. This refers to some infertile women whose cervical mucosa and endometrium contain lymphoid cells that produce immunoglobulin G (IgG) and A (IgA). If the cervical mucus of a woman contains anti-sperm IgG, IgA, and IgM, it will produce a local immune effect on sperm in the female reproductive tract.
4. Alloimmune factors: This refers to the male sperm and seminal fluid acting as antigens, which produce antibodies in the female body, leading to sperm agglutination or loss of sperm motility, thereby causing immunological infertility.

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