Patient's question:
We both have mild thalassemia. The amniocentesis results showed a heterozygous deletion of the SEA alpha-globin gene in amniotic fluid cells. What is the severity of thalassemia in the fetus?Doctor's answer:
Analysis of the condition: Hello, thalassemia has a certain genetic inheritance, so in your case, it is necessary to check for a history of heredity and conduct further tests to determine.Advice: Thalassemia is an autosomal genetic disease characterized by a deficiency or abnormality in the globin chains of hemoglobin. It is divided into α and β types, among which α-thalassemia, specifically Hbbart's, has the most significant impact on the fetus and pregnant woman, potentially causing fetal hemolytic edema, stillbirth in the late stages of pregnancy; the mother may develop severe complications such as pregnancy-induced hypertension and placental abruption. If one partner is affected, prenatal amniotic fluid and chorionic villus screening should be performed.