Patient's question:
Irregular menstruation, lower back pain.Doctor's answer:
1. Family genetic factors: Based on the high familial aggregation observed in the occurrence of polycystic ovary syndrome (PCOS), genetic factors are a major etiological component. Most cases of PCOS are associated with genetic abnormalities, while a few involve chromosomal abnormalities. This predisposing factor is difficult to avoid, and early detection and treatment are the only effective measures.2. Obesity, hyperinsulinemia: Some patients with PCOS, particularly those who are obese, may exhibit hyperinsulinemia and insulin resistance, suggesting that the condition is caused by insulin resistance. The causes of insulin resistance are varied, often resulting from dysfunction in the insulin receptor post-transduction system, though it can also be due to insulin receptor defects.
3. Long-term mental stress, medication, and disease effects: Due to mental stress, medication, or certain diseases affecting the hypothalamic-pituitary-ovarian axis regulatory function, abnormal production of androgens by ovarian stroma and follicular theca cells occurs. High androgen levels within the ovaries inhibit follicular maturation, leading to a series of PCOS-related symptoms such as amenorrhea and hirsutism.
4. Adrenal gland dysfunction: 50% of PCOS patients exhibit abnormal adrenal cortex function, often due to hyperfunction of the adrenal cortex, which leads to excessive androgen secretion and symptoms like anovulation. Diseases that cause adrenal cortex dysfunction primarily include adrenal tumors and adrenal cortex hyperplasia.