Theoretical and Practical Aspects of Modern Acute Organophosphorus Poisoning Treatment

Author: Zeng Fanzhong / Country:
Publisher:
Publishing Time: 2006-06-01
Features: This book comprehensively introduces the pharmacology, toxicology, and antidotal effects of the new cholinergic drug, Penehyclidine Hydrochloride. It is part of the "Decade 100 Projects" initiative under the Ministry of Health's second round of to rural and grassroots areas, specifically the "Penehyclidine Hydrochloride to Replace Atropine for Treating Organophosphorus Pesticide Poisoning" project. The content is advanced, scientifically sound, and highly practical, presented in an accessible manner. The book is divided into 7 chapters, providing an overview of the basic knowledge related to organophosphorus compounds/toxins and cholinergic nerves and their transmitters. It systematically discusses the mechanisms of organophosphorus poisoning (organophosphorus pesticides and chemical warfare agents, such as neurotoxic agents), the clinical manifestations and diagnosis of poisoning, the application of cholinesterase activity test kits, the principles and main measures for emergency treatment, and comprehensive symptomatic treatment. It delves deeply into new insights or perspectives on antidotal therapy and drug applications, as well as the latest research progress on organophosphorus poisoning worldwide. The book also addresses the causes and prevention of rebound, sudden death, intermediate syndrome, and delayed polyneuropathy in organophosphorus pesticide poisoning. Additionally, it provides a detailed introduction to the pharmacology, toxicology, and antidotal effects of the new cholinergic drug developed in China, Penehyclidine Hydrochloride, as part of the "Decade 100 Projects" initiative under the Ministry of Health's to rural and grassroots areas, specifically the "Penehyclidine Hydrochloride to Replace Atropine for Treating Organophosphorus Pesticide Poisoning" project. The book is advanced in content, scientifically sound, and highly practical, presented in an accessible manner. It holds significant practical reference value and is suitable for reference and study by medical staff in emergency departments, internal medicine, and grassroots healthcare settings. It can also serve as a reference book for the pharmacological and toxicological effects of the new drug, Penehyclidine Hydrochloride.