Patient's question:
How have I had three natural miscarriages in these three years. The check shows there are anti-sperm antibodies.Doctor's answer:
1. Blocking sperm from penetrating cervical mucus, antisperm antibodies can cause sperm to clump together, hindering sperm motility. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or affecting sperm motility. Additionally, they may have some impact on sperm metabolism and the function of sperm contraction proteins.2. Affecting the activity of sperm enzymes, inhibiting the dispersion of the zona pellucida and corona radiata, including:
① Acrosin: Promotes sperm penetration through the zona pellucida and facilitates sperm-egg fusion;
② Sperm hyaluronidase: Disperses the cumulus oophorus (corona radiata). Sperm antibodies primarily inhibit the activity of hyaluronidase, disrupting the dispersion of sperm.