Patient's question:
Fetal demise check, anticardiolipin positive, is this serious?Doctor's answer:
Hello, anticardiolipin antibody (ACA) is an autoantibody that targets negatively charged cardiolipin on the surface of platelets and endothelial cell membranes. It is a strong coagulation-active substance and can directly cause damage to vascular endothelial cells. This leads to thrombosis and changes in trophoblast cell function, forming placental infarction, intrauterine fetal death, and ultimately resulting in miscarriage. Specifically, a positive anticardiolipin antibody test may lead to adverse pregnancy outcomes such as recurrent miscarriage and fetal demise. It is important to seek medical treatment as early as possible. Treatment typically involves oral aspirin, intravenous immunoglobulin, heparin, and hormone therapy. Normal fertility can be restored after the antibody becomes negative. I hope this information is helpful to you.