Postpartum Diffuse Liver Damage, Cholestasis of Pregnancy

Patient's question:

After childbirth, diffuse liver damage, significant expansion of both intrahepatic and extrahepatic structures, marked abnormalities in the pancreas and spleen, normal size and shape of both kidneys, mild hydronephrosis, and mild separation and dilation of the collecting system. Current liver function tests show total bilirubin 214, direct bilirubin 144, and indirect bilirubin 66, which are significantly higher than normal, low blood sugar, slight edema on the body surface, and jaundice. What are these symptoms, and how should they be treated?

Doctor's answer:

General treatment involves bed rest, providing a low-fat, low-protein, high-carbohydrate diet to ensure sufficient calories. Glucose is administered intravenously to correct hypoglycemia; attention is paid to maintaining electrolyte balance and correcting acidosis.
Blood exchange or plasma exchange, used in foreign countries, involves exchanging three times the blood volume with blood, combined with hemodialysis, successfully treating a patient with AFLP (Acute Fatty Liver Pathology) and multi-organ failure. Plasma exchange therapy can clear irritant factors from the blood, replenish deficient clotting factors, reduce platelet aggregation, and promote vascular endothelial repair.
Component blood transfusion: Administering large amounts of frozen fresh plasma can achieve similar effects to plasma exchange therapy. Blood components such as red blood cells, platelets, human albumin, and fresh blood can be given as needed.
Liver protection therapy: Vitamin C, branched-chain amino acids (), adenosine triphosphate (ATP), coenzyme A, etc.

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