Patient's question:
I am considered a high-risk pregnant woman now. Recently, I finally got pregnant, and I've been feeling a bit unwell. My family suspects it might be fatty liver disease. Could you please tell me how to differentiate between acute fatty liver disease during pregnancy?Doctor's answer:
Hello, it's best to go to the hospital for a check-up!Intrahepatic cholestasis of pregnancy is characterized by itching, elevated transaminases, jaundice, and elevated bile acids. In contrast, AFLP does not involve itching or elevated bile acids. The histological changes in pregnancy cholestasis primarily involve bile stasis in the central hepatic capillaries, with bile deposition also observed in placental tissue. In AFLP, the liver cells are mainly infiltrated with fat droplets, while the placenta shows no significant changes.