Patient's question:
Can you get pregnant with a chromosomal translocation?Doctor's answer:
The male has a Robertsonian translocation. Theoretically, the sperm produced would be 1/6 normal, 1/6 balanced, and the rest would be unbalanced sperm, which could increase the early miscarriage rate in the female and the risk of congenital defects in the fetus. Although the theoretical probability of bad outcomes is relatively high, due to the large number of sperm released in a single ejaculation by the male and the rigorous internal selection process in the female's body, along with natural selection, the actual miscarriage rate is not as high. Therefore, the poor outcome of this pregnancy may be related to the male's balanced translocation, or it could be due to other factors during the early pregnancy. It is recommended to perform amniocentesis between the 16th and 20th weeks of pregnancy to rule out any adverse fetal conditions. The first suggestion involves a significant element of luck, but indeed, many of my patients have experienced good fortune and given birth to healthy children. This is also the most ethically and economically suitable choice for Chinese people.