Amniocentesis 4th chromosome 0.28mb duplication

Patient's question:

Hunan Jia Hui Amniocentesis Test Results: 4q21.1 (78060001-78340000)3, the size of the duplicated fragment is 0.28 MB. This sample has a copy number duplication of approximately 0.28 MB on the long arm of chromosome 4. Querying the public database shows that the pathogenicity is unknown.

Doctor's answer:

For a hybrid A/a, since A and a will segregate, it cannot be used as a seed. If cis configuration is obtained through unequal crossing over, it will not segregate and can fix heterosis, but this can only be used for traits controlled by a single gene and cannot be used for quantitative traits.

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