Patient's question:
Main symptoms: Onset time: 2007 Test results: 100Doctor's answer:
Hello: Antisperm antibodies are a complex pathological product that can affect both men and women, and their exact causes or etiology are not yet fully understood. The sperm and seminal fluid of men are specific antigens for women, and upon contact with the bloodstream, they can trigger immune reactions in both men and women, leading to the production of corresponding antibodies that hinder the combination of sperm and eggs, resulting in infertility. The aforementioned conditions fall under the category of immunological infertility. Female patients with positive antisperm antibodies often have a history of reproductive system inflammation such as endometritis, vaginitis, or tubulitis before the onset of their condition, which is particularly common in cases of tubal obstruction infertility. These patients frequently have a history of sexual intercourse during menstruation, postpartum lochia, or abnormal vaginal bleeding. Even if they have the opportunity to conceive, the fertilized egg may either be affected by the disease or weakened, making it highly susceptible to atrophy or death during the embryonic stage, leading to spontaneous abortion. In men, about 10% of infertile individuals have positive antisperm antibodies in their blood. Under normal circumstances, the testes and male reproductive tract are protected by a robust immune barrier, preventing sperm from coming into contact with the body's immune system, thus minimizing the occurrence of immune reactions. This condition is also caused by diseases. For example, inflammation of the male reproductive tract or other factors or etiologies that block the spermatic ducts can cause sperm to leak out, or the ligation and severance of the vas deferens can block the ducts, potentially leading to sperm antigens coming into contact with the body's immune system, resulting in the production of antisperm antibodies. This can cause sperm to aggregate, become immobilized, lose their normal vitality, and struggle to fertilize the egg. For immunological infertility, isolation therapy and immunosuppressive therapy are recommended. Early treatment is advised to avoid missing the optimal age for conception.