What is immunological infertility caused by sperm?

Patient's question:

In the few years since we got married, we initially didn't plan to have children. Now we want to have a child but can't, which has really upset us. We went to the hospital for a check-up and were told that I have immunological infertility. What does this mean? Will it affect our ability to have children?

Doctor's answer:

Hello! Immunological infertility refers to the fact that sperm are originally coated with many antigenic substances. Once sperm enter the bloodstream, if anti-sperm antibodies encounter them, they can interfere with the normal activity of sperm. This can cause trembling, affecting the ability of sperm to penetrate cervical mucus. Anti-sperm antibodies can also hinder sperm from penetrating the egg, which is known as immunological infertility. The blood-testis barrier is precisely the physiological mechanism formed to prevent this type of immunological infertility. It is clear that under normal conditions, but when reproductive organ inflammation causes obstruction of the spermatic ducts, the integrity of the blood-testis barrier can be disrupted. Sperm can then escape from the seminiferous tubules and enter the bloodstream, becoming the culprit behind immunological infertility. It is recommended to visit a reputable infertility specialist hospital for a comprehensive examination. The doctor will provide targeted treatment based on your condition. Wishing you early pregnancy and good health!

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