Patient's question:
Hello doctor, I would like to ask what causes semen to fail to liquefy? I have a condition of semen not liquefying, and I don't know how I got it. We really want to have a child, but we can't get pregnant—could this be related to the reason? How should I be treated? What are the factors that cause semen to fail to liquefy?Doctor's answer:
1. Mycoplasma, Chlamydia trachomatis, and Neisseria gonorrhoeae infection: If a patient is infected with mycoplasma, it can lead to dysfunction of the accessory glands, causing direct changes in semen composition, resulting in semen liquefaction failure and thus affecting fertility.2. Prostatitis: Prostatitis can cause liquefaction failure of semen. Experts explain that the liquefaction and coagulation of semen are regulated by coagulating proteins and liquefying factors in the semen. As enzymes that act as liquefying factors, when prostate secretion activity decreases, their activity weakens continuously, leading to liquefaction failure in semen.
3. Idiopathic non-liquefaction syndrome: Some patients with non-liquefiable semen also suffer from idiopathic non-liquefaction syndrome, which has very poor outcomes in clinical treatment.