Patient's question:
Hello doctor, I would like to learn what anti-sperm antibodies are, how treatable this condition is, and I currently want to have a child.Doctor's answer:
The Harm of Sperm Antibodies:Damage to Sperm:
① Damages sperm motility. The cervical mucus contains high levels of sperm antibodies, making it a difficult passage for sperm. After sperm come into contact with antibodies, they are easily adhered to protein clusters, losing their motility;
② Antibodies cause changes in the sperm membrane, thereby interfering with sperm capacitation;
③ Affects the release of hyaluronidase from the acrosome, thus inhibiting the acrosome reaction and preventing sperm from dissolving the egg membrane to enter and fertilize the egg;
④ After antibodies bind to sperm, they can activate the complement system, leading to sperm destruction, while also causing inflammatory reactions in the body.