Human radiation cytogenetics

Author: Bai Yushu
Publisher:
Publish Date: 2006-05-01
Features: This book is a specialized monograph on radiation cytogenetics, covering the main research methods, achievements, applications in biological dosimetry and other areas, as well as development trends in radiation cytogenetics in recent years both domestically and internationally. The book is divided into twenty chapters. Chapters 1 to 5 mainly introduce the general overview, theoretical foundation, and commonly used methods of radiation cytogenetics; Chapters 6 to 8 discuss radiation-induced chromosomal aberrations and dose-effect relationships; Chapter 9 focuses on solar radiation-induced chromosomal aberrations; Chapter 10 covers low-dose radiation-induced cellular adaptive responses; Chapter 11 presents methods and applications for estimating biological doses based on chromosomal aberrations; Chapter 12 explores other applications of chromosomal aberrations; Chapters 13 to 15 introduce methods for lymphocyte micronucleus determination and their applications in the field of radiation; Chapter 16 discusses methods for premature chromosome condensation and their applications in biological dose estimation; Chapters 17 and 18 introduce fluorescence in situ hybridization (FISH) techniques, their applications in radiomedicine, and related statistical issues in preclinical research. The appendices primarily include specific operational methods commonly used in radiation cytogenetics, such as chromosome, micronucleus, PCC, FISH methods; karyotypes of common chromosomal diseases; the toxicity of reagents commonly used in cytogenetic experiments; and statistical symbols and significance limits commonly used in statistics. This book is suitable for researchers, clinicians, educators, and grassroots workers in related fields such as radiobiology, radiomedicine, radiation health protection, radiation epidemiology, and clinical radiotherapy, as well as students and researchers in higher education institutions and related disciplines.