Patient's question:
I'm very curious about how many opportunities there are.Doctor's answer:
Hello: The normal infertility rate in women is about 15%, while it can be as high as 40% in patients with endometriosis. The reasons for infertility in severe endometriosis patients may be related to widespread adhesions of pelvic organs and tissues and weakened tubal peristalsis, which affect the release, uptake, and transport of oocytes and fertilized eggs. However, mild patients with no obvious pelvic anatomical abnormalities may also suffer from infertility. The cause of infertility is not solely due to local anatomical abnormalities. It is now widely believed that infertility in patients with ectopic endometrium may also be related to the following factors:1) Luteal phase deficiency: Endometriosis patients have fewer LH receptors on their follicles and luteal cells compared to normal women, leading to insufficient luteal secretion and affecting conception.
2) Luteinized unruptured follicle syndrome (LUFS): This condition is considered ovulatory dysfunction, where the follicle luteinizes but does not rupture. Although the patient's body temperature shows a biphasic pattern and the endometrium appears in the secretory phase, pregnancy is not possible. The diagnosis is based on laparoscopic examination: in the expected ovulation period, no ovulation pore is observed on the ovary surface 4–10 days later; the follicle continues to grow 2 days after the LH peak; and there is no sudden increase in estrogen and progesterone levels in the abdominal fluid during the menstrual cycle. Studies have confirmed that the incidence of LUFS in endometriosis patients is significantly higher than in normal women, leading to infertility. Konincks proposed that due to the presence of LUFS, the levels of estrogen and progesterone in the abdominal fluid are low, failing to suppress the implantation of endometrial cells that reflux into the abdomen, thus causing pelvic endometriosis. He believed that LUFS is the root cause of endometriosis. However, this theory has not been widely accepted.