Patient's question:
Patient Gender: Qin JuanDetailed Condition and Purpose of Consultation: Polycystic Ovary Syndrome
Duration of Current Illness: Unknown
Medical History: None
Previous Diagnoses and Treatment History and Effect: Polycystic Ovary Syndrome, took Clomiphene, and increased to two tablets
Ancillary Examinations: Hysteroscopy
Others:
Doctor's answer:
Hello, the main goal of PCOS treatment is to establish a normal ovulatory menstrual cycle, restore fertility, and eliminate hirsutism. Once a normal menstrual cycle is established, pregnancy can occur, the ovaries no longer produce excessive androgens, and hirsutism also disappears. The methods to restore a normal menstrual cycle are as follows.（1）Clomiphene, also known as Clomiphene Citrate or Serophene. It is now widely recognized as the first-line treatment for PCOS. Clomiphene induces the hypothalamus to release gonadotropin-releasing hormone, which in turn promotes the pituitary to release follicle-stimulating hormone (FSH), thereby promoting normal follicular development. Elevated FSH levels are key to inducing ovulation in PCOS patients. Clomiphene treatment can induce ovulation in more than 80% of patients. The specific dosage is 50 mg once daily, starting from day 5 of the menstrual cycle, for 5 consecutive days. Ovulation typically occurs 7–10 days after treatment. If treatment for 1–2 cycles is ineffective, the dose can be increased to 100 mg daily for 5 days. During treatment, basal body temperature is measured to observe for ovulatory biphasic patterns.
（2）Ovarian wedge resection, which involves removing a wedge of ovarian tissue. Before the introduction of clomiphene, the treatment for PCOS was ovarian wedge resection. The efficacy was significant. Most patients ovulated and became pregnant shortly after surgery. With the availability of clomiphene, ovarian wedge resection is rarely used today, reserved only for patients who do not respond to medication.
（3）Traditional Chinese Medicine. The method of invigorating blood and tonifying the kidneys to induce ovulation has shown good results.