Can chromosomes reproduce?

Patient's question:

Male
Wife's first pregnancy ended with a miscarriage in July. Ultrasound revealed hydrocephalus, cyclopia, corpus callosum agenesis, and a weak fetal heartbeat (similar to an adult's).
Auxiliary tests:
- Both partners' karyotypes
- Female, 29 years old: Normal results for genetic screening, karyotype
- Male, 30 years old: 46xy, (21p+?)
Detailed condition and consultation purpose:
- Can they have another child?
- Will this happen again? What are the chances?
- Can it be treated?
- Is IVF a viable option?
Thank you very much.

Doctor's answer:

Hello: It is very likely to reappear, but the probability is uncertain!