How is intrahepatic cholestasis of pregnancy caused?

Patient's question:

Patient Gender: I am a 6-month pregnant mother. Since the second month of pregnancy, I have been experiencing stomach pain. Starting from the fourth month, I noticed that my whole body was itchy, and the condition has been getting worse. I went to a specialized hospital for blood tests, but no abnormalities were found. The hospital prescribed several traditional Chinese medicine decoctions and recommended applying them all over the body, but there has been no improvement. What could be the cause of this? Will it affect the fetus?
Thank you.

Doctor's answer:

Hello: You can consider using external calamine ointment. Cholestasis syndrome is a pregnancy-specific complication, and its etiology is currently unclear. It may be related to factors such as female hormones, genetics, and the environment. Treatment aims to relieve itching symptoms, improve liver function, reduce blood bile acid levels, strengthen fetal monitoring, and prolong the gestational period. Ursodeoxycholic acid can be used for treatment. It is recommended that you promptly use medications such as cholestyramine and phenobarbital to relieve itching symptoms, lower blood bile acid levels, and improve fetal hypoxia symptoms.

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