Patient's question:
My girlfriend is very afraid of pain, she doesn't dare to get a tire fixed. But we can't have the baby now either, we haven't confirmed if we are pregnant yet? But we need to be prepared earlier. If we get pregnant, what medicine can be used to terminate the pregnancy directly without causing much pain?Doctor's answer:
Hello: Currently, the only painless abortion method is the painless abortion. Any other form of abortion will cause some degree of pain. However, medication abortion also requires actively going to the hospital for a detailed examination, and after the family members sign, the medication can be obtained.Mechanism of Action of Medication Abortion:
Mifepristone: The main function is as an antiprogesterone.
(1) As a progesterone antagonist, it can replace natural progesterone in acting on the endometrium, occupying the progesterone receptors on endometrial cells.
(2) Antiprogesterone action leads to necrosis of the decidua, shedding and bleeding, dissolving the corpus luteum, and stimulating the production of endogenous prostaglandins.
(3) Acts on the hypothalamus and pituitary, inhibiting the secretion of gonadotropins, which also leads to corpus luteum dissolution.
(4) Promotes the breakdown of cervical collagen fibers, softening the cervix.
(5) Enhances the sensitivity of uterine muscles to prostaglandins.
Prostaglandins: Commonly used include carboprost and misoprostol. Their mechanism of action is as follows:
(1) Causes contractions of the uterine smooth muscle.
(2) After uterine contractions, intrauterine pressure increases, leading to vasoconstriction of chorionic villi, local hypoxia, and necrosis and degeneration of the decidua, thereby disrupting the mechanisms that maintain early pregnancy.
(3) Inhibition of cervical collagen fiber synthesis results in a soft cervix, making it easier to dilate.
(4) In animals, it has been observed to dissolve the corpus luteum.
When these two drugs are used in combination, they achieve anti-implantation, cervical softening, and uterine contractions to induce abortion, making medication abortion a simple, safe, effective, low-side-effect, and low-pain method.
Indications:
1) Interruption of