Patient's question:
Doctor, hello!I am a pregnant woman who is about 6 months pregnant. Because I am type O blood and my partner is type A blood, I had a blood type antibody test, and the result was 1/128.
Could you please tell me if this is considered high and if treatment is needed?
Doctor's answer:
Hello: In cases of ABO blood type incompatibility between mother and child, not all children develop hemolytic disease, with the incidence rate being around 2.5%. This is partly due to the strength of the newborn's A (B) antigen, as well as the presence of A-type or B-type substances in the fetal body fluids. These blood group substances can reduce the affinity of maternal anti-A or anti-B antibodies for fetal A (B) red blood cells, thereby protecting the infant. On the other hand, it is also related to the genetic type of the child's father. ABO hemolytic disease can occur in the first pregnancy, and whether it develops in subsequent pregnancies or how severe the condition is depends on the genetic type of the child's father. If the father is a homozygous genotype, it is difficult to escape the disease in later pregnancies. If the father is a heterozygous genotype, the subsequent fetus may not necessarily develop the disease.