Patient's question:
Medical history: In February 2009, after 3 years of marriage, she was diagnosed with polycystic ovary syndrome during a check-up. Symptoms: obesity, excessive hair growth, and acne.Treatment history and effectiveness: Initially, she took Dian-35 orally, which regulated her menstrual cycle but did not result in pregnancy. Later, she took clomiphene, but still remained infertile.
Help needed: What treatment should we follow now?
Doctor's answer:
Polycystic ovary syndrome (PCOS) is a relatively common endocrine syndrome among women of reproductive age, not a unique disease but rather a clinical syndrome with multiple etiologies and highly variable manifestations. It is generally believed to be associated with dysfunction of the hypothalamic-pituitary-ovarian axis, adrenal gland disorders, genetic factors, metabolic factors, and others. A small number of PCOS patients have sex chromosome or autosomal abnormalities, and some have a family history. The pathogenesis of PCOS is complex, and what is widely recognized includes: ① high LH with normal or low levels of FSH; ② increased androgens; ③ relatively stable estrogen levels (E1 higher than E2); ④ insulin resistance (hyperinsulinemia); ⑤ morphological changes in ovarian tissue, such as multiple cystic follicles and stromal hyperplasia. Based on your description, the presence of polycystic ovary ultrasound findings does not necessarily mean you have PCOS. It is recommended that you visit a regular hospital and consult a gynecological endocrinology specialist, combining hormone tests and clinical symptoms for further diagnosis.