From Natural Products to the Creation of New Pesticides - Principles and Methods

Author: Wu Wenjun
Publisher:
Publish Date: 2006-03-01
Features: This book aims at the creation of new pesticides. From the perspective of agrochemistry, it first describes the extraction, separation, structural identification, and evaluation methods of active components from natural products, and then introduces the principles and methods for developing commercially available pesticides directly from plant extracts or microbial secondary metabolites. It also explores the principles and methods for optimizing natural lead structures, including bioisosteric substitution, pharmacophore modeling, quantitative structure-activity relationships (QSAR), and virtual screening. Additionally, it covers the study of pesticide mechanisms of action, particularly receptor localization, the isolation and structure of receptor proteins, and the principles and methods for discovering and researching new targets. The book provides two examples of natural product pesticide research. It serves as a reference for graduate students, researchers, and educators engaged in pesticide research and development, especially those focused on the creation of new pesticides.